"Transmission of Misfolded Proteins in Neurodegenerative Disorders: A Common Mechanism of Disease Progression"

Monday, September 25, 2017
2:30 PM - 4:00 PM (ET)
Event Type
Susan Penn
Distinguished Visitors Program

Distinguished Visitor Dr. Virginia Man-Yee Lee, John H. Ware 3rd Endowed Professor in Alzheimer's Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania.

Over the past 25 years, Dr. Lee’s research focus, in partnership with her long term collaborator Dr. John Trojanowski, has been and continues to be on elucidating mechanisms underlying neuron dysfunction and death in aging related human neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), frontotemporal degeneration (FTD), amyotrophic lateral sclerosis (ALS) and related tauopathies, synucleinopathies and TDP-43 proteinopathies. This research is pursued in multi-disciplinary studies using immunological, biochemical, molecular and morphological methods performed on human central nervous system tissues obtained postmortem and from neurosurgical procedures, on cerebral spinalfluid and blood samples from living patients and on in vitro model systems as well as on transgenic mouse models of human neurodegenerative diseases. Major accomplishments include discovery of tau, alphasynucleinand TDP-43 as the diseases proteins in AD, PD and ALS/FTD, respectively, elucidating the rolesof these proteins in neurodegeneration, advancing development of AD and PD biomarkers, pursuingpathological tau as a target for AD and FTD drug discovery, and advancing understanding of thetransmission of pathological tau and α-synuclein in cell mouse model systems which could explain disease progression in AD and PD. Because of the broad impact of their research, Lee and Trojanowski are among the top 10 most highly cited AD researchers and each of them has been recognized as ISI Highly Cited Researcher which has placed them among the top 10 most highly cited neuroscientists from 1997 to 2007. Dr. Lee’s h-index is 128.

Tea at 
2:15 PM

Sponsored by the Department of Biology in conjunction with the Distinguished Visitors Program.

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