B-Cell Clonal Expansions in Health and Disease

Monday, April 29, 2019
2:30 PM - 4:00 PM (ET)
Event Type
Susan Penn
î ºBiology-Distinguished Visitors

Distinguished Visitor Eline T. Luning Prak, associate professor of pathology and laboratory medicine,  Director, Human Immunology Core Facility, and faculty, clinical immunology laboratory, Hospital of the University of Pennsylvania
B cells are lymphocytes that produce antibodies.  Antibodies are proteins that bind to a wide range of different molecules and are important for immune defense.  During an immune response to a pathogen, B cells expressing antibodies that recognize the pathogen can become activated and undergo cell division (or clonal expansion).  We are interested in how large clones of B cells are distributed in the body and how they contribute to normal and pathologic immune responses. In the talk I will describe how we track B-cell clones in different tissues and over time in humans using next-generation sequencing based assays of antibody gene rearrangements. 
Tea at 2:15 p.m.
Sponsored by the Department of Biology in conjunction with the Distinguished Visitors Program 

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