B-Cell Clonal Expansions in Health and Disease

Monday, April 29, 2019
2:30 PM - 4:00 PM (ET)
Event Type
Lecture
Contact
Susan Penn
Department
î ºBiology-Distinguished Visitors
Link
https://ems-web.quaker.haverford.edu/MasterCalendar/EventDetails.aspx?EventDetailId=73792

Distinguished Visitor Eline T. Luning Prak, associate professor of pathology and laboratory medicine,  Director, Human Immunology Core Facility, and faculty, clinical immunology laboratory, Hospital of the University of Pennsylvania
 
B cells are lymphocytes that produce antibodies.  Antibodies are proteins that bind to a wide range of different molecules and are important for immune defense.  During an immune response to a pathogen, B cells expressing antibodies that recognize the pathogen can become activated and undergo cell division (or clonal expansion).  We are interested in how large clones of B cells are distributed in the body and how they contribute to normal and pathologic immune responses. In the talk I will describe how we track B-cell clones in different tissues and over time in humans using next-generation sequencing based assays of antibody gene rearrangements. 
 
Tea at 2:15 p.m.
 
Sponsored by the Department of Biology in conjunction with the Distinguished Visitors Program 

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